Research direction:
1. Preparation of large and mouse transgenic animal models / Transgenic Mouse/Rat Model
2. Developmental Biology of Cardiovascular
3. Metabolic disease
She has been engaged in scientific research in well-known universities in the United States for nearly 18 years, including developmental biology research and the construction of animal models of transgenic mice. And she has also published nearly 20 papers including internationally renowned journals such as Nature and Cell. From 2000 to 2011,she served as director of the Center for Transgenic Mice at Cornell University. And she returned to China in September 2011 and now works at the Institute of Translational Medicine of Nanchang University. She established the first transgenic animal center and technology platform in our province, and established a large-scale, mouse animal room, embryonic stem cell culture laboratory and cell molecular biology laboratory. Construction of animal models of transgenic mice, early embryo and sperm preservation, and in vitro fertilization techniques. In 2012,she was awarded the entrepreneurial talent of “Gan Po Yingcai 555 Project” in Jiangxi Province.

Representative Works / Selected Publication
1、Wang, L. F., Wang, X. N., Huang, C. C., Hu, L., Xiao, Y. F., Guan, X. H., Qian, Y. S., Deng, K. Y., and Xin, H. B. (2017) Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKalpha/SREBP1 signaling pathway, Lipids in health and disease 16, 82.
2、Feng, J., Huang, P., Shi, S., Deng, K. Y., and Wu, F. Y. (2017) Colorimetric detection of glutathione in cells based on peroxidase-like activity of gold nanoclusters: A promising powerful tool for identifying cancer cells, Analytica chimica acta 967, 64-69.
3、Jiang, M. X., Hong, X., Liao, B. B., Shi, S. Z., Lai, X. F., Zheng, H. Y., Xie, L., Wang, Y., Wang, X. L., Xin, H. B., Fu, M., and Deng, K. Y. (2017) Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation, Scientific reports 7, 42781.
4、Yuan, Q., Deng, K. Y., Sun, L., Chi, S., Yang, Z., Wang, J., Xin, H. B., Wang, X., and Ji, G. (2016) Calstabin 2: An important regulator for learning and memory in mice, Scientific reports 6, 21087.
5、Guan, X. H., Liu, X. H., Hong, X., Zhao, N., Xiao, Y. F., Wang, L. F., Tang, L., Jiang, K., Qian, Y. S., Deng, K. Y., Ji, G., Fu, M., and Xin, H. B. (2016) CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway, Oxidative medicine and cellular longevity 2016, 7410257.
6、Yuan, Q., Chen, Z., Santulli, G., Gu, L., Yang, Z. G., Yuan, Z. Q., Zhao, Y. T., Xin, H. B., Deng, K. Y., Wang, S. Q., and Ji, G. (2014) Functional role of Calstabin2 in age-related cardiac alterations, Scientific reports 4, 7425.
7、Xin, H., Deng, K., and Fu, M. (2014) Post-transcriptional gene regulation by RNA-binding proteins in vascular endothelial dysfunction, Science China-Life Sciences 57, 836-844.
9、J. VanEe, P. S., W. Wang, Y. Li, S. Zhang, R. Williams, K.Y. Deng, J. Pillardy, Q. Sun, T. Stelick, J. Spisak, E. Paronett, L. Cote, R. Cameron, J. Zhao, B. Hover, J. Kresovich, Y. Xin, M. Figueroa, R. Shaknovich, S. Monni, U. Unnsteinsdottir, R. Sherwood, C. Ptak, H. Yan, C. Bayles, G. Xia, R. Doran, R. Bukowski, C. Myers, L. Ponnala, S. Stefanov, M. Howard, J. Flaherty, A. Manocchia, E. Dodge,K. Smith, C. Aquadro, D. Lin, A. Melnick, W. Zipfel, P. Soloway, M. Jin, A. Clark, A. Siepel, J.K.C. Rose, G.S. Grills. (2010) Cornell University Life Sciences Core Laboratories Center, J Biomol Tech 21(3 Suppl), S71. Tallini, Y. N., Shui, B., Greene, K. S., Deng, K. Y., Doran, R., Fisher, P. J., Zipfel, W., and Kotlikoff, M. I. (2006) BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons, Physiological genomics 27, 391-397.
10、Xin, H. B., Deng, K. Y., Shui, B., Qu, S., Sun, Q., Lee, J., Greene, K. S., Wilson, J., Yu, Y., Feldman, M., and Kotlikoff, M. I. (2005) Gene trap and gene inversion methods for conditional gene inactivation in the mouse, Nucleic acids research 33, e14.
11、Ji, G., Feldman, M. E., Deng, K. Y., Greene, K. S., Wilson, J., Lee, J. C., Johnston, R. C., Rishniw, M., Tallini, Y., Zhang, J., Wier, W. G., Blaustein, M. P., Xin, H. B., Nakai, J., and Kotlikoff, M. I. (2004) Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle, The Journal of biological chemistry 279, 21461-21468.
12、Rishniw, M., Xin, H. B., Deng, K. Y., and Kotlikoff, M. I. (2003) Skeletal myogenesis in the mouse esophagus does not occur through transdifferentiation, Genesis (New York, N.Y. : 2000) 36, 81-82.
13、Xin, H. B., Deng, K. Y., Rishniw, M., Ji, G., and Kotlikoff, M. I. (2002) Smooth muscle expression of Cre recombinase and eGFP in transgenic mice, Physiological genomics 10, 211-215.
14、Xin, H. B., Senbonmatsu, T., Cheng, D. S., Wang, Y. X., Copello, J. A., Ji, G. J., Collier, M. L., Deng, K. Y., Jeyakumar, L. H., Magnuson, M. A., Inagami, T., Kotlikoff, M. I., and Fleischer, S. (2002) Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy, Nature 416, 334-338.
15、Kume, T., Deng, K., and Hogan, B. L. (2000) Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract, Development (Cambridge, England) 127, 1387-1395.
16、Kume, T., Deng, K., and Hogan, B. L. (2000) Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2, Mol Cell Biol 20, 1419-1425.
17、Winnier, G. E., Kume, T., Deng, K., Rogers, R., Bundy, J., Raines, C., Walter, M. A., Hogan, B. L., and Conway, S. J. (1999) Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles, Developmental biology 213, 418-431.
18、Kume, T., Deng, K. Y., Winfrey, V., Gould, D. B., Walter, M. A., and Hogan, B. L. (1998) The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus, Cell 93, 985-996.
19、Zhao, G. Q., Deng, K., Labosky, P. A., Liaw, L., and Hogan, B. L. (1996) The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse, Genes & development 10, 1657-1669.
20、Deng, K. Y., Wang, D. Y., and Qiu, P. (1993) [Protective effects of tetrandrine on calcium paradox in isolated rat heart], Yao xue xue bao = Acta pharmaceutica Sinica 28, 886-892.
21、Xin, H. B., and Deng, K. Y. (1990) [Classification, distribution and functions of 5-hydroxytryptamine receptors], Sheng li ke xue jin zhan [Progress in physiology] 21, 235-241.