Based on the Institute of Translational Medicine of Nanchang University, the Transgenic Animal Center was established in 2011 and has an experimental space of nearly 2,000 square meters, of which millions of clean mouse rooms (SPF animal houses) for producing and breeding transgenic mice. More than 1,000 square meters.

SPF animal room as the focus of the construction of the center, built a million barrier system, five breeding rooms (including large mouse laboratory), embryo cryopreservation room, microinjection room, animal carcass cryopreservation room, quarantine isolation room, wash Elimination, feed room, litter room, distribution room, etc. Its basic hardware facilities are well equipped and are now officially in operation. The center will strive to develop into the first AAALAC-certified animal center in Jiangxi Province.

The platform is equipped with two sets of micro-injection workbench and its auxiliary facilities, embryonic stem cell culture room, surgical operating room, animal feeding equipment and so on. It mainly conducts research on various key technologies of mouse transgene and production of transgenic mice, including target gene overexpression, gene knockout, and conditional knockout mice, and provides animal models and new drug screening models for related disease research. Provide support for high-level research projects in universities and various scientific research institutions in our province.
 

The center also has a large laboratory, a cell room, equipped with fluorescent inverted microscope, full-wavelength microplate reader, fluorescence microscope, fluorescent mirror, flow cytometer, cryogenic high-speed centrifuge, blood cell analyzer and other experimental instruments to meet The needs of researchers for animal experiments. Professor Deng Keyu, director of the center, once served as director of the Cornell University Animal Center, returned to China in 2009, mainly engaged in the preparation of rat and mouse transgenic animal models, cardiovascular developmental biology, metabolic disease research. At present, the research team led by Professor Deng Keyu has a total of 1 doctoral degree, 3 doctoral students, 7 master students and 2 laboratory technicians.
Articles published by Professor Deng Keyu:
[1] Wang, L. F., Wang, X. N., Huang, C. C., Hu, L., Xiao, Y. F., Guan, X. H., Qian, Y. S., Deng, K. Y., and Xin, H. B. (2017) Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKalpha/SREBP1 signaling pathway, Lipids in health and disease 16, 82.
[2] Feng, J., Huang, P., Shi, S., Deng, K. Y., and Wu, F. Y. (2017) Colorimetric detection of glutathione in cells based on peroxidase-like activity of gold nanoclusters: A promising powerful tool for identifying cancer cells, Analytica chimica acta 967, 64-69.
[3] Jiang, M. X., Hong, X., Liao, B. B., Shi, S. Z., Lai, X. F., Zheng, H. Y., Xie, L., Wang, Y., Wang, X. L., Xin, H. B., Fu, M., and Deng, K. Y. (2017) Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation, Scientific reports 7, 42781.
[4] Jiang, M., Deng, K., Jiang, C., Fu, M., Guo, C., Wang, X., Wang, X., Meng, F., Yang, S., Deng, K., Chen, T., and Xin, H. (2016) Evaluation of the Antioxidative, Antibacterial, and Anti-Inflammatory Effects of the Aloe Fermentation Supernatant Containing Lactobacillus plantarum HM218749.1, Mediators of inflammation.
[5] Yuan, Q., Deng, K. Y., Sun, L., Chi, S., Yang, Z., Wang, J., Xin, H. B., Wang, X., and Ji, G. (2016) Calstabin 2: An important regulator for learning and memory in mice, Scientific reports 6, 21087.
[6] Guan, X. H., Liu, X. H., Hong, X., Zhao, N., Xiao, Y. F., Wang, L. F., Tang, L., Jiang, K., Qian, Y. S., Deng, K. Y., Ji, G., Fu, M., and Xin, H. B. (2016) CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway, Oxidative medicine and cellular longevity 2016, 7410257.
[7] Wu, L., Luo, M., Deng, R., Liu, T., Deng, K., and Lin, S. (2016) Synthesis and antitumour activity of diorganotin biscarboxylates containing Silicon, Chemical Research and Application 28, 716-719.
[8] Xue, C., Shi, X., Fang, X., Tao, H., Zhu, H., Yu, F., Ding, X., Liu, M., Fang, F., Yang, F., Wei, Z., Chen, T., Wang, Z., Wang, G., Cheng, X., Wei, J., Lin, Y., Deng, K., Wang, X., and Xin, H. (2016) The "Pure Marriage" between 3D Printing and Well-Ordered Nanoarrays by Using PEALD Assisted Hydrothermal Surface Engineering, ACS applied materials & interfaces 8, 8393-8400.
[9] Zhan, W., Han, T., Zhang, C., Xie, C., Gan, M., Deng, K., Fu, M., and Wang, J. B. (2015) TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins, PloS one 10, e0142596.
[10] Zeng, Y. F., Xiao, Y. S., Lu, M. Z., Luo, X. J., Hu, G. Z., Deng, K. Y., Wu, X. M., and Xin, H. B. (2015) Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma, Experimental and molecular pathology 98, 260-267.
[11] Yuan, Q., Chen, Z., Santulli, G., Gu, L., Yang, Z. G., Yuan, Z. Q., Zhao, Y. T., Xin, H. B., Deng, K. Y., Wang, S. Q., and Ji, G. (2014) Functional role of Calstabin2 in age-related cardiac alterations, Scientific reports 4, 7425.
[12] Liao Qihua, Lin Sen, Deng Ruihong, Huang Zhiqiang, Deng Keyu, and Yan Zhaohua. (2015) Synthesis, Structure and Anticancer Activity of 2-Mercaptobenzothiazole Complexes Containing Silicon Dialkyltin (IV), Organic Chemistry 35, 1923-1928.
[13] Han, R. W., Xu, H. J., Zhang, R. S., Wang, P., Chang, M., Peng, Y. L., Deng, K. Y., and Wang, R. (2014) Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation, Neurobiology of learning and memory 107, 32-36.
[14] Xin, H., Deng, K., and Fu, M. (2014) Post-transcriptional gene regulation by RNA-binding proteins in vascular endothelial dysfunction, Science China-Life Sciences 57, 836-844.
[15] Wang Dan, Zheng Huaiyu, Shi Shuizhen, He Xiangqin, Deng Keyu. (2014) Methodology for isolation and purification of mouse islets, Journal of Nanchang University (Medical Sciences), 5-8, 107.
[16] J. VanEe, P. S., W. Wang, Y. Li, S. Zhang, R. Williams, K.Y. Deng, J. Pillardy, Q. Sun, T. Stelick, J. Spisak, E. Paronett, L. Cote, R. Cameron, J. Zhao, B. Hover, J. Kresovich, Y. Xin, M. Figueroa, R. Shaknovich, S. Monni, U. Unnsteinsdottir, R. Sherwood, C. Ptak, H. Yan, C. Bayles, G. Xia, R. Doran, R. Bukowski, C. Myers, L. Ponnala, S. Stefanov, M. Howard, J. Flaherty, A. Manocchia, E. Dodge, K. Smith, C. Aquadro, D. Lin, A. Melnick, W. Zipfel, P. Soloway, M. Jin, A. Clark, A. Siepel, J.K.C. Rose, G.S. Grills. (2010) Cornell University Life Sciences Core Laboratories Center, J Biomol Tech 21(3 Suppl), S71.
[17] Tallini, Y. N., Shui, B., Greene, K. S., Deng, K. Y., Doran, R., Fisher, P. J., Zipfel, W., and Kotlikoff, M. I. (2006) BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons, Physiological genomics 27, 391-397.
[18] Xin, H. B., Deng, K. Y., Shui, B., Qu, S., Sun, Q., Lee, J., Greene, K. S., Wilson, J., Yu, Y., Feldman, M., and Kotlikoff, M. I. (2005) Gene trap and gene inversion methods for conditional gene inactivation in the mouse, Nucleic acids research 33, e14.
[19] Ji, G., Feldman, M. E., Deng, K. Y., Greene, K. S., Wilson, J., Lee, J. C., Johnston, R. C., Rishniw, M., Tallini, Y., Zhang, J., Wier, W. G., Blaustein, M. P., Xin, H. B., Nakai, J., and Kotlikoff, M. I. (2004) Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle, The Journal of biological chemistry 279, 21461-21468.
[20] Kotlikoff, M. I., Kannan, M. S., Solway, J., Deng, K. Y., Deshpande, D. A., Dowell, M., Feldman, M., Green, K. S., Ji, G., Johnston, R., Lakser, O., Lee, J., Lund, F. E., Milla, C., Mitchell, R. W., Nakai, J., Rishniw, M., Walseth, T. F., White, T. A., Wilson, J., Xin, H. B., and Woodruff, P. G. (2004) Methodologic advancements in the study of airway smooth muscle, The Journal of allergy and clinical immunology 114, S18-31.
[21] Rishniw, M., Xin, H. B., Deng, K. Y., and Kotlikoff, M. I. (2003) Skeletal myogenesis in the mouse esophagus does not occur through transdifferentiation, Genesis (New York, N.Y. : 2000) 36, 81-82.
[22] Xin, H. B., Deng, K. Y., Rishniw, M., Ji, G., and Kotlikoff, M. I. (2002) Smooth muscle expression of Cre recombinase and eGFP in transgenic mice, Physiological genomics 10, 211-215.
[23] Xin, H. B., Senbonmatsu, T., Cheng, D. S., Wang, Y. X., Copello, J. A., Ji, G. J., Collier, M. L., Deng, K. Y., Jeyakumar, L. H., Magnuson, M. A., Inagami, T., Kotlikoff, M. I., and Fleischer, S. (2002) Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy, Nature 416, 334-338.
[24] Kume, T., Deng, K., and Hogan, B. L. (2000) Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract, Development (Cambridge, England) 127, 1387-1395.
[25] Kume, T., Deng, K., and Hogan, B. L. (2000) Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2, Mol Cell Biol 20, 1419-1425.
[26] Winnier, G. E., Kume, T., Deng, K., Rogers, R., Bundy, J., Raines, C., Walter, M. A., Hogan, B. L., and Conway, S. J. (1999) Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles, Developmental biology 213, 418-431.
[27] Kidson, S. H., Kume, T., Deng, K., Winfrey, V., and Hogan, B. L. (1999) The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye, Developmental biology 211, 306-322.
[28] Kume, T., Deng, K. Y., Winfrey, V., Gould, D. B., Walter, M. A., and Hogan, B. L. (1998) The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus, Cell 93, 985-996.
[29] Zhao, G. Q., Deng, K., Labosky, P. A., Liaw, L., and Hogan, B. L. (1996) The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse, Genes & development 10, 1657-1669.
[30] Deng, K. Y., Wang, D. Y., and Qiu, P. (1993) [Protective effects of tetrandrine on calcium paradox in isolated rat heart], Yao xue xue bao = Acta pharmaceutica Sinica 28, 886-892.
[31] Xin, H. B., and Deng, K. Y. (1990) [Classification, distribution and functions of 5-hydroxytryptamine receptors], Sheng li ke xue jin zhan [Progress in physiology] 21, 235-241.

The current staff structure of the center is as follows:

The central facilities and corresponding management components include: