Xin Hongbo, born in November 1959, a member of the Jiu San Society, a native of Jiangxi, a professor of education, a professor of education, a postgraduate degree, a doctoral degree, a doctoral tutor, and a vice president of Nanchang University. He is currently a member of the American Society of Biophysics and the American Diabetes Association, and the Chinese Society of Biophysics, the Committee of Neurophysical Physics and Neuroinformatics (NBPC). Currently, he is mainly engaged in the physiology, biochemistry and molecular biology research of myocardial, skeletal and smooth muscle sarcoplasmic reticulum calcium release channels. His thesis has been published in internationally renowned academic journals such as Nature, Journal of Biological Chemistry, Nucleic Acids Research, Proc Natl Acad SCI USA, and Circulation Research and other publications. He has published more than 60 papers and has one monograph. The main research directions are: 1) the role of sarcoplasmic reticulum or endoplasmic reticulum calcium mobilization in excitatory-contraction coupling of muscle cells such as myocardium, femoral muscle and smooth muscle, and excitatory-secretion coupling of endocrine glands such as islet β cells. 2) functional genomics studies in mice; 3) development of genetic and bioengineered drugs. Now obtained an international patent: "Vectors for conditional gene inactivation; inventor: Hong-Bo Xin, Michael I. Kotlikoff; patent number: US Patent-7449179 ; Authorization date: November 11, 2008". There are 3 domestic authorized patents and 40 patent applications.
First, have been rewarded:
1.Xin Hongbo (1/1), FKBP12.6 on the regulation of cardiac sarcoplasmic reticulum calcium release (RyR2) and heart disease, Jiangxi Provincial People's Government, Jiangxi Natural Science Award, First Prize, 2013.
2. Xin Hongbo (1/1), Chinese Overseas Chinese Contribution Award (Innovative Talents), All-China Returned Overseas Chinese Federation, 2010.
3. Xin Hongbo (1/4), Chinese Overseas Chinese Contribution Award (Innovation Team), All-China Returned Overseas Chinese Federation, 2014 (Xin Hongbo, Wang Xiaolei, Wang Jianbin, Deng Keyu).
4. Xin Hongbo (2/5), Cross-application of Microorganism and Nanotechnology, Jiangxi Provincial People's Government, Jiangxi Natural Science Award, Second Prize, 2016 (Wang Xiaolei, Xin Hongbo, Zhu Hui).
Second, research projects
In the research project:
1.The National Fund Committee's “Major Research Program” incubation project: TRIM65-mediated VCAM-1 post-transcriptional modification of vascular endothelial cells on vascular inflammation and atherosclerosis and its mechanism (Project No.: 91639106 direct funding of 650,000, implementation) Year: 2017-2019, Project Leader: Xin Hongbo
2.“973 Program” of the Ministry of Science and Technology: pathogenesis and intervention study of arrhythmia, third topic: ventricular sarcoplasmic protein instability and arrhythmia (item number: 2013CB531103, total funding: 6.24 million, implementation period: 2013 -2017, Project leader: Xin Hongbo).
Completed project:
1.The National Fund Committee's “Major Research Program” incubation project: CD38 regulates the cellular signaling pathway of macrophage function and its role in atherosclerosis (Project No.: 91391913, total funding: 850,000, duration of implementation: 2014- In 2016, the project leader: Xin Hongbo).
2.National Fund Committee “Face Project”: functional changes in the hypothalamic-pituitary-gonadal axis induced by genetically modified mice and gender-related cardiac hypertrophy (Project No. 81270202, total funding: 800,000, duration of implementation: 2013-2016 Year, Project Leader: Xin Hongbo).
3.National Fund Committee “Spot Project”: Mechanism of CD38 gene regulation of ventricular remodeling after acute myocardial ischemia/reperfusion injury (Project No.: 81070095, total funding: 330,000, duration of implementation: 2011-2013, project Person in charge: Xin Hongbo).
4.Ministry of Science and Technology “Major New Drug Special Project”: Preclinical Drug Research for Infectious Diseases (Project No.: 2011ZX09102-009, Total Funding: 34,491,100, Execution Year: 2011-2013, General Project Leader: Xin Hongbo. Among them The sub-subject of Hong Bo is “Research on anti-HBV peptide drugs that specifically block the formation of core protein subunits”)
5.Project of the Jiangxi Provincial Department of Education: The establishment of a therapeutic human-derived monoclonal antibody transgenic mouse technology platform and its product development (total funding: 1 million, implementation period: 2012-2015, project leader: Xin Hongbo).
6.Jiangxi Province Biopharmaceutical and Biotechnology Collaborative Innovation Center Project: Jiangxi Provincial People's Government (total funding of 20 million, implementation period 2016-2019, project leader: Xin Hongbo).
7.Ministry of Education “Changjiang Scholars and Innovation Team Development Plan” Innovation Research Team Fund: Genetic basis and prevention research related to hereditary cardiovascular disease and sudden death (Project No.: IRT1141, total funding: 300 million, implementation period: 2012- In 2014, the team leader: Hong Kui; Xin Hongbo is the main research backbone).
8.Ministry of Education, Doctoral Supervisor Fund: Molecular mechanism of FKBP12.6 deletion leading to cardiac hypertrophy in male mice (Question No.: 20113601110001, total funding: 120,000, implementation period: 2012.01-2014.12, project leader: Xin Hongbo)
9.Jiangxi Provincial Government: "Gan Po Talent 555 Project" (Leading Talents Training Plan), selected batches: the first batch in 2010, implementation period: 2011-2016, total funds: 1 million, project leader: Xin Hongbo.
10.Jiangxi Provincial Department of Education: “311 Project” (total funding: 23.33 million, implementation period: 2011-2015, project leader: Xin Hongbo)
Third, the patent
Authorized patents:
1. Xin Hongbo, Michael I. Kotlikoff: Internationally licensed invention patent "Vectors for conditional gene inactivation", date of authorization: 2008.11.11, patent number: US, US Patent-7449179 .
2. Xin Hongbo, Wu Sisi, Zhang Wei: Recombinant protein that specifically blocks the assembly and replication of hepatitis B virus and its preparation method, date of authorization: 2011.04.20, patent n umber: China, ZL200810305544.3;
3. Chen Tingtao, Xin Hongbo, Wei Qiang: Establishment of a method for isolating memory B cells in vitro, date of authorization: 2016.08.24, patent number: China, ZL201410284551.5.
4. Chen Tingtao, Wei Qiang, Xin Hongbo: A preparation method of human vaginal microecological preparation-probiotic condom, date of authorization: 2016.08.24, patent number: China, ZL201410621898.4.
Aply for patent:
1. Xin Hongbo, Chen Tingtao, Wang Xin, Zhou Haiting, Qiu Bojun. Application of a natural fecal flora transplantation in the treatment of intestinal diseases, 2015.09, China, application number 201510619679.7
2. Xin Hongbo, Chen Tingtao, Wang Xin. Application of a natural oral bacterial transplantation in the treatment of oral diseases, 2015.09, China, application number 201510619689.0
3. Xin Hongbo, Chen Tingtao, Deng Wei, Wei Qiang, Hu Ping. Method for screening respiratory syncytial virus memory B cells by nano magnetic beads method, 2014.12, China, application number 201410726313.5
4. Xin Hongbo, Wang Xin, Chen Tingtao. Method for preparing probiotic embolism and capsule for treating inflammation in women, 2014.11, China, application number 201410621675.8
5. Xin Hongbo, Wang Xin, Chen Tingtao. Method for preparing Bifidobacterium infantis ATCC 15697 and aloe co-fermented beverage, 2014.11, China, application number 201410607585.3
6. Xin Hongbo, Wang Xin, Chen Tingtao. Method for preparing Lactobacillus plantarum ATCC 8014 and aloe co-fermented beverage, 2014.11, China, application number 201410607551.4
7. Xin Hongbo, Chen Tingtao, Wei Qiang, Wang Wei, Deng Yu. Method for preparing G and F proteins for detecting human respiratory syncytial virus antibody, 2014.04, China, application No. 201410139592.5
8. Xin Hongbo, Chen Tingtao, Wei Qiang. A preparation method for inducing memory B cells to differentiate into plasma cells in vitro, 2014.06, China, application number 201410284437.2
9. Xin Hongbo, Chen Tingtao, Meng Fanjing. Preparation method of probiotic air dispersion preparation, 2016.09, China, application number 201610809419.4
10. Xin Hongbo, Chen Tingtao, Wang Xin. Preparation method and application of attenuated Salmonella typhimurium expressing GLP-1, 2016.5, China, 201610318452.3
11. Wang Xiaolei, Xin Hongbo, Yu Fen, Xue Chaowen, Shi Xiaotong A preparation method of nano antibacterial anti-noise earplugs, application date August 2, 2014, publication date December 24, 2014, China, application number 201410377655.0
12. Wang Xiaolei, Xin Hongbo, Shi Xiaotong, Xue Chaowen, Xiang Zhuo, Song Xiang A preparation method of visible light excitation antibacterial coating containing nano cuprous oxide, application date January 8, 2016, publication date June 15, 2016 Application No. 201610009061.3
13. Wang Xiaolei, Xin Hongbo, Dong Lina, Liu Chunbiao, Yu Fen, Shi Xiaotong, Liu Miaoxing A preparation method of carbon aerogel for air filtration, January 29, 2016, China, application number 20161006434.X
14. Wang Xiaolei, Xin Hongbo, Xiang Zhuo A preparation method of antibacterial hydrogel for touch screen surface, August 19, 2016, China, application number 201610689027.5
15. Chen Tingtao, Xin Hongbo, Wang Xin. Vector strain expressing DNase I, AIF or recombinant single-chain antibody integrated with the toxin and application of the strain, 2016.12, China, application number 201611112222.8
16. Chen Tingtao, Xin Hongbo, Wang Xin. Attenuated Salmonella typhimurium-mediated eukaryotic plasmid transfection method, 2016.12, China, application number 201611112192.0
17. Chen Tingtao, Xin Hongbo, Wang Xin. Method for preparing bacteria and antibody combined with double-targeted anti-small solid tumor drug, 2016.12, China, application number 201611112221.3
18. Chen Tingtao, Xin Hongbo, Wang Xin. A strain for expressing AIF and a recombinant single-chain antibody integrated with AIF and application of the strain, 2016.12, China, application number 201611112189.
19. Chen Tingtao, Xin Hongbo, Meng Fanjing. Preparation method of vaginal probiotic sanitary napkin, 2016.09, China, application number 201610809493.2
20. Chen Tingtao, Xin Hongbo, Yang Shaoguo. Method for preparing artificial microecological preparation for enhancing immunity of infants and young children, 2016.09, China, application number 201610839502.2
21. Chen Tingtao, Xin Hongbo, Yang Shaoguo. Preparation method for restoring symbiotic microbe rag of caesarean section newborn, 2016.09, China, application number 201610839501.8
22. Chen Tingtao, Xin Hongbo, Wang Xin, Zhou Haiting. Method for preparing probiotic aloe mask, 2016.6, China, 201610367765.8
23. Chen Tingtao, Xin Hongbo, Wang Xin. Preparation method and application of using dominant bacteria of intestinal wall to replace natural flora, 2016.5, China, 201610295304.4
24. Chen Tingtao, Xin Hongbo, Yang Shaoguo. A method for screening microorganisms having anti-cancer activity in feces, 2016.5, China, 201610310988.0
25. Chen Tingtao, Xin Hongbo, Wang Xin. Preparation method and application of Lactococcus lactis secreting GLP-1, 2016.5, China, 201610298373.0
26. Chen Tingtao, Xin Hongbo, Lai Zhiqiang, Wang Xin. Method for preparing Lactobacillus plantarum ATCC 8014 and Nanfeng tangerine fermented beverage, 2015.02, China, application number 201510072994.2
27. Chen Tingtao, Xin Hongbo, Liu Huan, Wang Xin. Method for preparing Lactobacillus plantarum ATCC 8014 and Eucommia ulmoides fermented beverage, 2015.02, China, application number 201510073232.4
28. Chen Tingtao, Xin Hongbo, Wang Xin. Method for preparing Streptococcus thermophilus ATCC 14485 and aloe co-fermented beverage, 2014.11, China, application number 201410607552.9
29. Chen Tingtao, Xin Hongbo, Wang Xin. Method for preparing lactobacillus rhamnosus ATCC 7469 and aloe co-fermented beverage, 2014.11, China, application number 201410607668.2
30. Chen Tingtao, Xin Hongbo, Wang Xin. Method for preparing human intestinal micro-ecological system, 2014.04, China, please call 201410139415.7
31. Chen Tingtao, Xin Hongbo, Deng Wei, Zhang Yuji, Tang Xianyao, Zhou Haiting. Application method of artificial culture vaginal flora transplantation in gynecological inflammation, 2015.09, China, application number 201510619424.0
32. Chen Tingtao, Xin Hongbo, Deng Wei, Zhang Yuji, Tang Xianyao, Qiu Bojun. Application method of natural vaginal flora transplantation in gynecological inflammation , 2015.09, China, application number 201510619567.1
33. Chen Tingtao, Xin Hongbo, Wang Xin, Zhang Fengcai, Huang Weihua. Application of artificial culture of fecal flora transplantation in the treatment of intestinal diseases, 2015.09, China, application number 201510619640.5
34. Chen Tingtao, Xin Hongbo, Wang Xin, Yang Shaoguo, Mo Ling. Application of artificial culture oral bacterial transplantation in the treatment of oral diseases, 2015.09, Ch ina, application number 201510619648.1
35. Chen Tingtao, Xin Hongbo, Meng Fanjing, Wang Xin. A dialysis bag separation culture method for studying the relationship between microorganisms, 2015.12, China, application number 2015111013560.1
36. Chen Tingtao, Wang Xin, Xin Hongbo. Application of aloe capsule in probiotic fermentation products, 2015.05, China, application number 201510234567.X
37. Chen Tingtao, Deng Wei, Xin Hongbo. Application of attenuated Salmonella VNP20009 in gene expression, 2015.05, China, application number 201510223921.9
38. Chen Tingtao, Deng Wei, Xin Hongbo. Method for preparing probiotic chewing gum, 2014.11, China, application number 201410621757.2
39. Chen Tingtao, Wang Xin, Xin Hongbo. A method for screening micro-ecological preparations with high adhesion ability in pig intestines, 2014.08, China, application number 201410403216.2
40. Chen Tingtao, Wei Qiang, Xin Hongbo, Deng Wei, Hu Ping. Method for capturing memory B cells against respiratory syncytial virus by Elisa method, 2014.04, China, application number 201410726538.5
Representative work
[1] Xin HB, Rogers K, Qi Y, Kanematsu T, Fleischer S. Three amino acid residues determine selective binding of fk506-binding protein 12.6 to the cardiac ryanodine receptor. J Biol Chem. 1999;274:15315-15319
[2] Xin HB, Senbonmatsu T, Cheng DS, Wang YX, Copello JA, Ji GJ, Collier ML, Deng KY, Jeyakumar LH, Magnuson MA, Inagami T, Kotlikoff MI, Fleischer S. Oestrogen protects fkbp12.6 null mice from cardiac hypertrophy. Nature. 2002;416:334-338
[3] Xin HB, Deng KY, Rishniw M, Ji G, Kotlikoff MI. Smooth muscle expression of cre recombinase and egfp in transgenic mice. Physiol Genomics. 2002;10:211-215
[4] Xin HB, Deng KY, Shui B, Qu S, Sun Q, Lee J, Greene KS, Wilson J, Yu Y, Feldman M, Kotlikoff MI. Gene trap and gene inversion methods for conditional gene inactivation in the mouse. Nucleic Acids Res. 2005;33:e14
[5] Zhang X, Tallini YN, Chen Z, Gan L, Wei B, Doran R, Miao L, Xin HB, Kotlikoff MI, Ji G. Dissociation of fkbp12.6 from ryanodine receptor type 2 is regulated by cyclic adp-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res. 2009;84:253-262
[6] Ge Y, Jiang W, Gan L, Wang L, Sun C, Ni P, Liu Y, Wu S, Gu L, Zheng W, Lund FE, Xin HB. Mouse embryonic fibroblasts from cd38 knockout mice are resistant to oxidative stresses through inhibition of reactive oxygen species production and ca(2+) overload. Biochem Biophys Res Commun. 2010;399:167-172
[7] Yu H, Stoneman V, Clarke M, Figg N, Xin HB, Kotlikoff M, Littlewood T, Bennett M. Bone marrow-derived smooth muscle-like cells are infrequent in advanced primary atherosclerotic plaques but promote atherosclerosis. Arterioscler Thromb Vasc Biol. 2011;31:1291-1299
[8] Gan L, Jiang W, Xiao YF, Deng L, Gu LD, Guo ZY, Zhou ZC, Wu D, Xin HB. Disruption of cd38 gene enhances cardiac functions by elevating serum testosterone in the male null mice. Life Sci. 2011;89:491-497
[9] Gan L, Ni PY, Ge Y, Xiao YF, Sun CY, Deng L, Zhang W, Wu SS, Liu Y, Jiang W, Xin HB. Histone deacetylases regulate gonadotropin-releasing hormone i gene expression via modulating otx2-driven transcriptional activity. PLoS One. 2012;7:e39770
[10] Xin H, Deng K, Fu M. Post-transcriptional gene regulation by rna-binding proteins in vascular endothelial dysfunction. Sci China Life Sci. 2014;57:836-844
[11] Han XJ, Wei YF, Wan YY, Jiang LP, Zhang JF, Xin HB. Development of a novel liposomal nanodelivery system for bioluminescence imaging and targeted drug delivery in erbb2-overexpressing metastatic ovarian carcinoma. Int J Mol Med. 2014;34:1225-1232
[12] Zeng YF, Xiao YS, Lu MZ, Luo XJ, Hu GZ, Deng KY, Wu XM, Xin HB. Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma. Exp Mol Pathol. 2015;98:260-267
[13] Xue C, Shi X, Fang X, Tao H, Zhu H, Yu F, Ding X, Liu M, Fang F, Yang F, Wei Z, Chen T, Wang Z, Wang G, Cheng X, Wei J, Lin Y, Deng K, Wang X, Xin H. The "pure marriage" between 3d printing and well-ordered nanoarrays by using peald assisted hydrothermal surface engineering. ACS Appl Mater Interfaces. 2016;8:8393-8400
[14] Guan XH, Hong X, Zhao N, Liu XH, Xiao YF, Chen TT, Deng LB, Wang XL, Wang JB, Ji GJ, Fu M, Deng KY, Xin HB. Cd38 promotes angiotensin ii-induced cardiac hypertrophy. J Cell Mol Med. 2017
[15] Jiang M, Deng K, Jiang C, Fu M, Guo C, Wang X, Meng F, Yang S, Chen T, Xin H. Evaluation of the antioxidative, antibacterial, and anti-inflammatory effects of the aloe fermentation supernatant containing lactobacillus plantarum hm218749.1. Mediators Inflamm. 2016;2016:2945650
Domestic and foreign academic status of academic groups
2006-present Member of the Committee of Neurophysical Physics and Neuroinformatics (NBPC) of the Chinese Society of Biophysics;
2010-present Member of the 13th Final Review Expert Review Team of the National Natural Science Foundation of China;
In 2007, the National Ministry of Education “intellectual engineering” review expert;
In 2010, the Ministry of Science and Technology's “Major New Drug Creation” and “International Science and Technology Cooperation Program” review experts;
1994-present member of the American Society of Biophysics;
2001-present Member of the American Diabetes Association