Professor Fu Mingui, doctoral tutor. The 83-year-old alumni of our school received a doctorate in 2000 and studied under Professor Tang Chaoshu, a well-known scholar at the Peking University School of Basic Medicine. From 2000 to 2007, he was a postdoctoral fellow at the University of Texas Southwestern Medical Center in the United States. He was an assistant professor at the University of Central Florida School of Biomedical Sciences and the University of Missouri School of Medicine in 2007-2009 and 2010-2015, respectively. He has been a visiting professor at the Institute of Translational Medicine of Nanchang University since January 2016. Since January 2016, he has been appointed as an associate professor at the University of Missouri School of Medicine and chairman of the Department of Basic Medicine. His main research directions are: 1) regulation of innate immunity and inflammation; 2) signal transduction in macrophage activation; 3) negative regulation of Toll-like receptor signaling pathway; 4) molecular signaling of vascular endothelial injury and repair Conduction; 5) Novel target studies of human inflammatory diseases such as atherosclerosis, sepsis and viral infection. He has been engaged in teaching and research for many years, and his research papers have been published in internationally renowned academic journals, such as “Circulation”, “J Biol Chem”, “Circ Res”, “PNAS”, etc., and published 63 papers and 6 articles. , compiled a book chapter 1, participated in the domestic and foreign conference reports 20 times. He also participated in the review of 15 internationally renowned journals such as “Circulation”, “Cardiovascular Research” and “Scientific Reports”. here are 8 research projects involved and hosted, of which 6 are completed and 2 are under study.
Teaching
Participate in the teaching of undergraduate and post-doctoral programs, including “Basic Medical Foundation”, “Industrial Perspective Seminar”, “Biotechnology Methods: Drug Discovery Trends”, “Disease Molecular Biology”, and Frontiers of Biomolecular Science” , "Advanced Course in Cardiovascular Science" and "Graduate Course".
Honors and awards
Florida State Health Department New Investigator Award (2008)
American Diabetes Association Junior Faculty Award (2003)
American Heart Association Travel Award (2003)
Keystone Symposium Scholarship (2003)
American Heart Association Postdoctoral Fellowship (2002)
Third Prize of Science and Technology Progress of Guangzhou Municipal Government (1998)
Second Prize of Science and Technology Progress of Shanxi Education Bureau (1998)
Project support
Projects in progress:
1. NIH/NIAID 1R21AI103618 ($415,250) (NCE) Post-transcriptional regulation of cytokine production 05/01/2014-04/30/2017 Role: PI
2. UMRB award ($48,125) Enhancing expression of MCPIP1 as a therapeutic strategy for vascular inflammation 02/01/2016-12/31/2017 Role: PI
Concluding items:
1.NIH/NHLBI  1R21HL098794-A1  ($412,500)  Role of MCP-induced protein 1 in regulating NF-κB signaling and macrophage activation  01/01/2011-06/30/2014
Role: Principle Investigator
2.American Heart Association 09BGIA2460030 ($132,000)    MCPIP1-mediated p65 sumorylation and macrophage activation 07/01/2009-06/30/2012
Role: Principle Investigator
3.Florida State Department of Health JEK_NIR Grant_14395 ($375,000)  
Role of MCPIP1 in Nicotine-induced Repression of Macrophage Inflammation
07/01/2008-12/31/2009   Role: Principle Investigator
4.UCF In-House Grant UCF22209005 ($7,500)  Thymus-expressed cytokine and vascular inflammation.  07/01/2008-06/30/2009   Role: Principle Investigator
5.   American Diabetes Association Junior Faculty Award (7-03-JF-18) ($405,000)   Role of Ras-related GTPase Rad in Diabetic Vascular Remodeling
      7/01/2003-6/30/2006    Role: Principle Investigator
6.   American Heart Association Postdoctoral Fellowship (0225214B) ($70,000)  
      Transcriptional regulation of peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells. 7/01/2002-6/30/2004  Role: Principle Investigator
The main representative works:
(1) Fu M, Zhang J, Tseng YH, Cui T, Zhu X, Xiao Y, Mou Y, De Leon H, Chang MM,Hamamori Y, Kahn CR, Chen YE. Rad GTPase Attenuates Vascular Lesion Formation by Inhibition of Vascular Smooth Muscle Cell Migration. Circulation. 2005,101:1071-1077.
(2) Fu M, Zhang J, Lin Y, Zhu X, Ehrengruber MU, Chen YE. Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-gamma 1 gene expression in human aortic smooth muscle cells. J Biol Chem. 2002, 277:26808-14.
(3) Fu M, Zhang J, Zhu X, Myles DE, Willson TM, Liu X, Chen YE. Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem. 2001, 276:45888-94.
(4) Fu M, Zhu X, Wang Q, Zhang J, Song Q, Zheng H, Ogawa W, Du J, Chen YE. Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway. Circ Res. 2001, 89:1058-1064.
(5) Fu M* & Blackshear PJ. RNA metabolism in immune regulation: a focus on CCCH-zinc finger proteins. Nature Rev. Immunol. 2017, 17:130-143.
(6) Huang S, Liu S, Fu JJ, Wang TT, Yao X, Kumar A, Liu G, Fu M*. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. J Biol Chem. 2015, 290:20782-92.
(7) Guo F, He H, Fu ZC, Huang S, Chen T, Papasian CJ, Morse LR, Xu Y, Battaglino RA, Yang XF, Jiang Z, Xin HB, Fu M*. Adipocyte-derived PAMM suppresses macropha ge inflammation by inhibiting MAPK signalling. Biochem J. 2015, 472:309-18.
(8) Xin H, Deng K, Fu M*.Post-transcriptional gene regulation by RNA-binding proteins in vascular endothelial dysfunction. Sci China Life Sci. 2014 , 57(8):836-44.
(9) Huang S, Qi D, Liang J, Miao R, Minagawa K, Quinn T, Matsui T, Fan D, Liu J, Fu M*. The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages. Cell Signal. 2012, 24:569-576.
(10) Qi D, Huang S, Miao R, She ZG, Quinn T, Chang Y, Liu J, Fan D, Chen YE, Fu M*. Monocyte chemotactic protein-induced protein 1 (MCPIP1) suppresses stress granule formation and determi nes apoptosis under stress. J Biol Chem. 2011, 286:41692-41700.
(11) Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, Kolattukudy PE and Fu M*. MCP-induced protein 1 deubiquitinating TRAFs and negatively regulate JNK and NF-κB signaling. J Exp Med. 2010, 207:2959-2973.
(12) Liang J, Lei T, Song Y, Yanes N, Qi Y, Fu M*. RNA-destabilizing factor tristetraprolin negatively regulates NF-kappaB signaling. J Biol Chem. 2009, 284:29383-90.
(13) Liang J, Wang J, Asim A, Kolattukudy PE, Fu M*. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem. 2008, 283:6337-6346.
(14) Liang J, Song W, Tromp G, Kolattukudy PE, and Fu M*. Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. PLoS ONE. 2008, 3(8):e2880.
Domestic and foreign academic status of academic groups
Chair of Faculty, Department of Basic Medical Science, UMKC (2016)
Secretary of Faculty, Department of Basic Medical Science, UMKC (2014)
Budget Committee, Department of Basic Medical Science, UMKC (2014)
Council on Selection interviewer, School of Medicine, UMKC (2011)
Admission and Recruitment Committee, School of Biological Science, UCF (2009)
Graduate Symposium Committee, School of Biological Science, UCF (2009)
The Academy of Cardiovascular Research Excellence (2011)
American Society for Biochemistry and Molecular Biology (2008)
American Heart Association (2002)
American Diabetes Association (2002)