Deng Libin, Associate Professor, Master Instructor
Nanchang University Institute of Translational Medicine PI
Email: ncu_bioinfor@163.com
Educational experience:
2004-2007: Ph.D., Beijing Institute of Genomics, Chinese Academy of Sciences
2001-2004: Master of Tongji Medical College, Huazhong University of Science and Technology
1996-2001: Tongji Medical University, Bachelor
work experience:
2008-present: Associate Professor, Department of Medicine, Nanchang University
2007-2008: Assistant Researcher, Beijing Institute of Genomics, Chinese Academy of Sciences
Current main research directions:
He focuses on tumors and cardiovascular diseases; using high-throughput omics techniques to systematically discover and interpret the molecular mechanisms involved in disease development. It is mainly aimed at the discovery of rare transcripts, the determination of alternative splicing patterns, and the construction of transcriptional regulatory networks; and the use of nucleic acid markers to develop kits for early diagnosis of diseases.
Scientific research topics and funding:
1.2017.1-2020.12: National Natural Science Foundation of China Regional Project "Group-based screening of PPARA-related rSNP and its synergistic pathogenic mechanism in hypercholesterolemia" (81660041)
2.2013.1-2016.12: National Natural Science Foundation of China Regional Program "Group Teaching of Familial Hypercholesterolemia-Related Functional Mutations and Establishment of a Knockout Mouse Model" (81260021)
3.2009.1-2011.12: National Natural Science Foundation of China “Selecting the Role of Population Differentiation and the Formation of Chinese Specific Genetic Background” (30871384)
4.2013.1-2015.12: The genetic marker discovery and functional inference of the Han nationality's human body phenotypic characteristics (GJJ13091).
5.2012.1-2014.12: The role of the liver immune-related pathway in the high glucose and high fat tolerance mechanism in rats in the Jiangxi Natural Science Foundation Youth Project (20114BAB215019).
6.2010.1-2011.12: Jiangxi Provincial Department of Education project "Jiangxi population dementia candidate
Awards and patents:
In 2013, he was appraised as “the object of training young scientists in Jiangxi Province”
In 2011, he was appraised as “the seventh batch of young and middle-aged teachers in colleges and universities in Jiangxi Province”
Mainly published articles (*Corresponding author):
doi: 10.1007/s12035-015-9331-y. Epub 2015 Jul 31. doi: 10.1007/s12035-016-9869-3.
1.Deng L#, Hou L#, Zhang J, Tang X, Cheng Z, Li G, Fang X, Xu J, Zhang X*, Xu R*. Polymorphism of rs3737597 in DISC1 Gene on Chromosome 1q42.2 in sALS Patients: a Chinese Han Population Case-Control Study. Mol Neurobiol. 2017 Jul;54(5):3162-3179.
2.Hu Y#, Deng L#, Zhang J, Fang X, Mei P, Cao X, Lin J, Wei Y, Zhang X, Xu R. A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland. Mol Neurobiol. 2016 Sep;53(7):4302-18.
3.Xie T#, Deng L#, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X*, Xu R*. A genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Neurobiol Aging. 2014, 35(7):1778.e9-1778.e23.
4.Tang X#, Deng L #, Xiong H#, Li G#, Lin J, Liu S, Xie J, Liu J, Kong F, Tu G, Peng H, Liang S*. Expression Profiles of Skeletal Muscle and Liver Implicate MAPK Signaling Pathways in Diabetes Pathology. INDIAN J MED RES , 2014 , 140(6):744-755.
5. Wang Li#, Xu Yanmei, Cheng Zhujun, Xiong Zhaoping, Deng Libin*; Progress in genetics of cholesterol metabolism disorders; Genetics, 2014, 36 (9): 857-863.
6. Tang Xiaoli#, Deng Lianrui, Zhang Pengxia, Lin Jiari, Liu Yang, Xu Jinsong, Deng Libin*; Genome-wide association study of type 2 diabetes and related traits; Chinese Journal of Gerontology, 2013, 33(19): 4918-4922 .
7.Beall C, Cavalleri G, Deng L, Elston R, Gao Y, Knight J, Li C, Li J, Liang Y, McCormack M, Montgomery H, Pan H, Robbins P, Shianna K, Tam S, Tsering N, Veeramah K, Wang W, Wangdui P, Weale M, Xu Y, Xu Z, Yang L, Zaman M, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng Y. (2010). Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. PNAS ,107(25): 11459-11464.（IF = 9.38）
8.Deng L, Zhang Y, Kang J, Liu T, Zhao H, Gao Y, Li C, Pan H, Tang X, Wang D, Niu T, Yang H, Zeng C. (2008). An Unusual Haplotype Structure on Human Chromosome 8p23 Derived from the Inversion Polymorphism. Hum Mutat, 29(10): 1209-1216. (IF = 6.47)
9.Deng L, Zhang D, Richards E, Tang X, Long F, Fang J, Wang Y. (2009) Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human autosomes. J. Genet. Genomics, 36(12): 703-709. (IF = 0.83)
10.Deng L, Tang X, Kang J, Wang Q and Zeng C. (2007). Scanning for signatures of geographically restricted selection based on population genomics analysis. Chinese Sci. Bull, 52(19): 2649-2656. (IF = 0.72)
11.Gao Y*, Liu H*, Deng L*, Zhu G, Xu C, Li G, Liu S, Xie J, Liu J, Kong F, Wu R, Li G, Liang S. (2011). Effect of emodin on neuropathic pain transmission mediated by P2X(2/3) receptor of primary sensory neurons. Brain Res Bull, 84(6):406-13.（IF = 2.18）
12.Luo C*, Deng L*, and Zeng C. (2004). High throughput SNP genotyping with two mini-sequencing assays. Acta Biochim. Biophys. Sin, 36: 379-384 .(IF = 0.93)
13.Luo C*, Deng L*, Zhou J, Lin W and Zeng C. (2004). High throughput SNP genotyping with FP-TDI. Prog. Biochem. Biophys, 31(8): 731-735. (IF = 0.19)
14.Deng L, Tang XL, Chen W, Lin J, Lai Z, Liu Z, Zhang D. (2010). Scanning for Genomic Regions Subject to Selective Sweeps Using SNP-MaP Strategy. Genomics Proteomics Bioinformatics, 8(4): 256-261
15.Deng L, Tang X, Hao X, Chen W, Yu Y, Zhang D, Zeng C. (2011). Genetic Flux Between H1 and H2 Haplotypes of the 17q21.31 Inversion in European Population. Genomics. Proteomics & Bioinformatics, 9(3): 113-118.
16.Cheng F, Chen W, Elliott R, Deng L, Zeng C. (2009). SNP@Evolution: a hierarchical database of positive selection on the human genome. BMC EVOL BIOL, 9: 221. (IF = 4.55)
17.Zhang D, Chen J, Deng L, Li Y. (2009). Evolutionary Selection Associated with the Multi-function of Overlapping Genes in the Hepatitis B Virus. Infection, Genetics and Evolution, 10(1):84-88. (IF = 2.91)
18.Zhu B, Wang H, Shen C, Fan A, Yang G, Qin X, Jin T, Xie T, Deng L, Lucas R, Lian Z. (2011). Diversity of killer cell immunoglobulin-like receptor genes in the Bai ethnic minority of Yunnan, China. Scand J Immunol. 73(4):284-92 (IF =1.93)
19.Zhu B, Yang G, Shen C, Qin H, Fan S, Deng L, Chen F, Chen L, Wang H, Wang Z, Lucas R, Lian Z. (2010). Population genetic analysis of 15 autosomal STR loci in the Russian population of northeastern Inner-Mongolia, China. Mol Biol Rep. 37(8):3889-95 (IF =1.46)
20.Zhu B, Yang G, Shen C, Qin H, Liu S, Deng Y, Fan S, Deng L, Chen F, Zhang P, Fang J, Chen L, Wang H, Wang Z, Lucas R. (2010). Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations. J Zhejiang Univ Sci B,11(2): 127-35. (IF =1.67)
21.Zhu B, Wang H, Shen C, Deng Y, Yang G, Wu Q, Xu P, Qin H, Fan S, Huang P, Deng L, Lucas R, Wang Z. (2010). Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China. Hum Immunol. 71(11):1116-23 .(IF = 2.55)
22.Wang H, Zhu B, Shen C, Fan A, Song T, Liu J, Qin H, Deng L, Fan S, Huang Q, Guo Y, Fang J, Zhang P, Yan C. (2011). Diversity distributions of killer cell immunoglobulin-like receptor genes and their ligands in the Chinese Shaanxi Han population. Hum Immunol. 72(9):733-40. (IF = 2.55)
23.Tang X*, Deng L*, Zhang D, Lin J, Wei Y, Zhou Q, Li X, Li G, Liang S. (2012). Gene2DGE: a Perl package for gene model renewal with digital gene expression data. Genomics Proteomics Bioinformatics, 10(1):51-4.
24.Tang X*, Deng L*, Li G, Liu S, Lin J, Xie J, Liu J, Kong F, Liang S. (2012). Analysis of gene expression profile of peripheral ganglia in early stage type Ⅱ diabetic rats. Yi Chuan. 34(2):198-207.
25. Wang Yan, Tang Yuli, Chen Guangguang, Xiao Wei, Fang Jin, Long Fei, Deng Libin*; (2010); Using HapMap data to find the "candidate region" selected in the human genome; Journal of Nanchang University, 34(3) :273-275
26. Hao Xiangwen, Deng Libin, Zeng Changqing; (2008); The role of gene conversion on the formation of HLA polymorphisms on the same chromosome; Inheritance, 30(11); 1411-6
27. Rao Dan, Jiang Hong, Zeng Qiuyu, Guo Heping, Wang Min, Li Minghui, Deng Libin; (2005); Relationship between C469T polymorphism of adhesion molecule ICAM-1 gene and coronary heart disease; Journal of Clinical Cardiology, 21(11) :648-650
28. Zhu Chuanhong, Liu Yan, Deng Libin, Liu Liang; (2005); Study on DNA damage induced by tetramine in rats; Journal of Forensic Medicine, 21(1): 27-29
29. Liu Yan, Zhu Chuanhong, Deng Libin, Liu Liang; (2004); Comet electrophoresis detection of DNA damage induced by tetramine; Chinese Journal of Forensic Medicine, 19(5): 278-283
30. Zhang Shiwei, Liu Shixin, Deng Libin, Guo Xuerong, Chen Xinshan, Zhang Yiqi; (2004); Immunohistochemical study of dephosphorylation of left ventricular myocardium Cx43 in acute myocardial ischemia and sudden death; Journal of Forensic Medicine, 20(3): 136-142
31. Deng Libin, Yu Chunying, Yang Qingen; (2003); Relationship between nuclear DNA degradation and death time in mouse skeletal muscle cells; Chinese Journal of Forensic Medicine, 18(5): 273-275
32. Deng Libin, Shao Jianming, Xiong Zhiyong, Xiong Jiaqiang, Xiong Danqun, Fang Jin, Long Fei, Chen Luguang, Xiao Wei, Wang Yan (2011); DNA barcode construction of seven snakes based on 16S rRNA gene in Jiangxi; Journal of Nanchang University, 35(1): 95-102
33. Li Handong, Li Feifei, Zhang Dake, Deng Libin*; (2011); Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in microbial genome research; Journal of Jining Medical College, 34(1)