Professor Deng Yaguang, Ph.D. In 1992, he obtained his Ph.D. from the National Ocean University of Tokyo, Japan. From 1993 to 1996 and 1996-1998, he was a postdoctoral fellow in the Department of Pathology at the University of Florida Medical School and the Department of Molecular Biology at Stanford University. He has studied and worked in Japan for 9 years. He has studied and worked in the United States for more than 20 years. He has in-depth comparison and understanding of Eastern and Western science and technology and corporate structure. He has participated in the Japanese Human Genome Project, Diabetes Genetics and Prad Willi and Angelman. Disease gene mapping, single-cell gene chip analysis, design and production of automated instruments with independent intellectual property rights, worked in Merck Pharmaceuticals, Aofei Biochip, Leica Biomedical Instruments and other large international companies, product development and clinical transformation with rich experience. The main research directions are: 1) High-sensitivity biomolecule detection, including single-cell bacteria, single-molecule virus and biohazard components; 2) design, production and application of biomedical instruments for individual instruments, bio-detection systems Design and establishment; 3) Biological single-molecule chip detection system technology and product development oriented to biomedical research and development. He has published 30 research papers, with more than 1,490 citations, 7 reports and monographs, more than 50 reports at home and abroad, 3 patents granted, 12 public patents, 15 scientific research projects, and Hubei. There are hundreds of special experts in the province, and many awards such as the Innovation and Entrepreneurship Leadership of the Overseas Chinese Affairs Office.
Professional and work experience
2016-present  uest Professor, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, China.
2013-2016 Chairman, Advanced Gene Diagnostics Inc, San Jose, CA, USA
2009-2013,  enior Researcher, Stanford University School of Medicine, Stanford, CA, USA. His research interests include cancer biology, individual medicine, and translation medicine.
2005-2009, Senior Researcher, R&D Manager, Applied Imaging Corp/Genetix/Leica, CA, USA. Y developed cancer cell enrichment, detection and identification methods, instruments and reagent products, put them into the market, and achieved good sales.
Leading blood circulation cancer cell testing programs include clinical collaboration with Stanford University, University of Vermont, University of Hamburg-Eppendorf (Germany) and BC Cancer Center (Canada).
2001-2004, Senior Researcher, NuGEN Technologies, San Carlos, CA, USA. Successfully developed and marketed a variety of DNA/RNA amplification products and successfully applied single-cell gene amplification products to Affymetrix GeneChip and Agilent biochip analysis on.
2000-2001, Researcher, Affymetrix, Santa Clara, CA, USA. Experts in gene amplification, fragmentation and labeling, and GeneChip analysis.
1996-1998, Postdoctoral Fellow, Molecular Biology, Stanford, CA, USA. Responsible for research on gene regulation topics.
1993-1996, Postdoctoral Fellow, Department of Pathology, University of Florida School of Medicine, Gainesville, Florida, USA. Genes related to genetic syndromes such as diabetes, obesity, and AS/PWS.
1992-1993, Researcher, Biochemistry Laboratory, Japan Human Genome Engineering and Human New Protein Exploration Project.
Honors and awards
1978-1982 University Scholarship, Huazhong Agricultural University, Wuhan, China
1982-1985, staying in school with the total score of the first place in the department
1986 China's Ministry of Education, Agricultural College, Japanese Language and Literature Examination, the first place to study abroad in Japan
1986-1992 Japanese Ministry of Education, full scholarship
1992-1993 Japanese Ministry of Education, Doctoral Research Scholarship
1993-1996 Pathology Scholarship, Postdoctoral Research in Pathology, University of Florida School of Medicine, USA
1996-1998 Stanford University Postdoctoral Research Scholarship
2010 Wuhan Independent High-tech Development Zone “3551 Talent Plan” was selected Winner of the 10th Huachuang Association “Hua Chuang Cup” Outstanding Project Award (the top 3 in the world's 20 winners in all industries, the first in the biological series).
2011 Xiangyang Longzhong Talent Plan was selected
2013 Hubei Province 100 experts selected
2013 Yichang Three Gorges Talents Program was selected
2013 Nanjing Xuanwu District 321 Talent Competition, second place (second prize)
2013 State Council Overseas Chinese Affairs Office Key Overseas Chinese Entrepreneurship Team Award Leader
2014 Second Prize of the 9th Chunhui Cup Entrepreneurship Competition
2014 Hubei Academician Expert Workstation
2015 Hubei Provincial Academician Expert Workstation
Professional society
2006-present Member of the American Society of Cytology
2006-present American Cancer Society
1993-present American Genetic Society
1990-1995 Japan Biochemical Molecular Biology Society
1986-1988 President, China University of Science and Technology, Mie University, Japan
1990-1995 Director of the China Association of Science and Technology, Executive Director, Minister of Science and Technology, one of the main founders
2009-present Vice President, Hubei Association of Northern California, USA
2011-present Vice President of Overseas Chinese High-Tech Association, Executive Director, Minister of Biomedical Sciences
2014-present President of Meihua Biomedical Instrument Professional Association
2010-present Reviewers of various international magazines:
Journal of Medical Genetics
American Journal of Human Genetics
Journal of Pathology
Breast Cancer Research
BMC Cancer
PlosOne
Journal of Immunology
Single Cell Biology
Major works
1．Deng G et al: A new magnetic enrichment medical device allows highly sensitive detection and purely analysis of rare tumor cells from body fluids. Submitted.
2．Deng G, Zhang J, Tian F, Jeffrey SS: Isolation and mutation analysis of tumor cells from blood, bone marrow and body fluids of cancer patients with magnetic manipulation and automated device. Prepared.
3．Zhang H, Deng G, Jeffrey SS. Xen ograft TNBC tumors model for drug sensitivity testing. Submitted.
4．Deng G, Zhang H, Powell AA, Jeffrey SS. Comparison of single cell gene expression profile between circulating tumor cells and bone marrow tumor cells. Submitted.
5．Deng G, Zhang H, Jeffrey SS. Chromosome 5q6 deletion with aggressive tumor cell metastasis. Revised.
6．Zhang H, Cohen AL, Krishnakumar S, Wapnir IL, Veeriah R, Deng G, Coram MA, Piskun CM, Longacre TA, Herrler M, Frimannsson DO, Telli ML, Dirbas FM, Matin AC, Dairkee SH, Larijani B, Bild AH, Glinsky GV, Jeffrey SS. Patient-derived xenografts of triple negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition. Breast Cancer Research 2014 16:R36.
7．Deng G, Krishnakumar S, Powell AA, Zhang H, Mindrinos MN, Telli ML, Davis RW, Jeffrey SS. Single cell mutational analysis of circulating tumor cells in breast cancer reveals heterogeneity, discordance between tissues, and mutation persistence in cultured tumor cells from bone marrow. BMC Cancer 14:456, 2014.
8．Liu W, Deng Y, Liu Y, Gong WR, Deng W: Stem cell models for drug discovery and toxicology studies. J Biochem Mol Toxicol. 27:17-27. 2013.
9．Liu Q, Deng Y, Luo LH, Yu YM, Yin J, Li DK, Ke F, Lei L, Gong WR: The mechanism of 5-fluorouracil inducing B7-H1 in colon cancer and hepatocellular carcinoma cell lines. Chin J Exp Surg. 29: 2498-2499, 2012.
10．Powell AA, Talasaz AH, Zhang H, Coram MA, Reddy A, Deng G, Telli ML, Advani RH, Carlson RW, Mollick JA, Sheth S, Kurian AW, Ford JM, Stockdale FE, Quake SR, Pease RF, Mindrinos MN, Bhanot G, Dairkee SH, Davis RW, Jeffrey SS. Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS One. 2012;7(5):e33788.
11．Deng G, Herrler M, Burgess D, Manna E, Krag D, Burke JF. Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients. Breast Cancer Res. 10: R69. 2008.
12．Dafforn A, Chen P, Deng G, Herrler M, Iglehart DM, Koritala S, Lato SM, Pillarisetty S, Purohit R, Turner L, Wang M, Wang S, Kurn N.  Ribo-SPIA™, a rapid isothermal RNA amplification method for gene expression analysis.  In “Biochips as pathways to drug discovery”, Carmen A, Hardiman G, eds., CRC Press, pp261-279, 2006.
13．Singh R, Maganti R, Jabba S, Wang M, Deng G, Heath J, Kurn N, Wangemann P. Microarray based comparison of four amplification methods for nanogram amounts of total RNA. Cell Physiology, Dec. 21, 2004.
14．Dafforn A, Chen P, Deng G, Herrler M, Iglehart D, Koritala S, Lato S, Pillarisetty S, Purohit R, Wang M, Wang S, Kurn N. Linear mRNA amplification from as little as 5ng total RNA for global gen e analysis.  BioTechniques, 37 (5): 854-857, 2004.
15．Homey B, Deng G, Zlotnik A.  Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis.  J. Immunol., 164(12):6621-6632, 2000.
16．Glenn CC, Deng G, Michaelis RC, Tarleton J, Phelan MC, Surh L, Yang TP, Driscoll DJ. DNA methylation analysis with respect to prenatal diagnosis of the Angelman and Prader-Willi syndromes and imprinting. Prenat Diagn. 20(4): 300-306, 2000.
17．Deng G, Maclaren NK, Huang HS, Zhang LP, She, JX. No primary association between the 308 polymorphism in the tumor necrosis factor  promoter region and insulin-dependent diabetes mellitus.  Human Immunology, 45, 137-142, 1996.
18．Kobatake E, Mitomo K, Haruyama T, Aizawa M, Deng GY, Kato S.  On-Off Switching of Enzymatic Reaction By Recombinant Calmodulin on a Solid-Phase Matrix.  Bioconhugate Chem., 7(1), 126-130, 1996.
19．Deng G, Muir A, Maclaren NK, She JX.  Association of LMP2 and LMP7 Genes within the Major Histocompatibility Complex with Insulin-Dependent Diabetes Mellitus: Population and Family Studies.  Am. J. Hum. Genet. 56:528-534, 1995.
20．Deng Y. Gene and disease therapy. Japanese and Chinese Medicine. 1:17-18, 1993.
21．Deng Y, Oshiro T, Takashima F. Diploid and triploid hybrids of ranbow trout Onchrhynchus mykiss. Aquaculture. 40(2):1-8, 1992.
22．Kashiwagi M, Deng Y, Iwai T. Change of susceptibility to thermal shock in developing eggs of Japanese halitut, Paraclichtys olivaceus. Aquaculture. 40(1):1-5, 1992.
23．Oshiro T, Deng Y, Takashima F. Growth and survival of diploid and triploid hybrids of masu salmon Oncorhynchus masou. Bull Japan Soc Sci Fish. 57(10):1851-7, 1991.
24．Kashiwagi M, Deng Y, Iwai T. Changes in thermal tolerance of eggs of wrase Halicoeres polilopterus during development. Bull Fac Bio Mie Univ. 5:91-5, 1991.
25．Kashiwagi M, Deng Y, Iwai T. Change of susceptibility to thermal shock in developing eggs of pond smelt, Hypomesus tranpacificus. Aquaculture, 39(3):321-5, 1991.
26．Kashiwagi M, Deng Y, Iwai T. Upper limiting temperatures for the hatching of Japanese whiting, Sillago japonica eggs and variations of the temperatures during egg development. Aquaculture. 38(1):7-11, 1990.
27．Deng Y, Kashiwagi M, Iwai T. The egg sensitivity at different developmental stages of Sillago japonica to thermal shock, drop shock and ultraviolet irradiation. J Fish China. 14(2):95-104, 1990.
Reports and monographs
1.Deng Y. Human Calmodulin cloning, expression and its binding protein assay. Sagami Chemical Research Institute Report IV, 1991.
2.Deng Y, Zhang C, Liang Z, Cao D, Huang Y, and Liang Z. (Edited by Deng Y). Research Achievements of Chinese doctoral scientists in Japan. Nikkei Press, 1-545, 1992.
3.Deng Y. Human new protein genes cloning, sequencing from Human HT1080 cDNA library. Sagami Chemical Research Institute Report II, 1-21, 1992.
4.Deng Y. Human new protein genes cloning, sequencing from Human U937 cDNA library. Sagami Chemical Research Institute Report III, 29-37, 1992.
5.Deng Y. beta-actin cloning, expression, purification and its binding protein assay. Sagami Chemical Research Institute Report III, 1-19, 1993.
6.Deng Y. Human 90kDa heat shock protein cDNA cloning, expression and its binding protein analysis in vitro and in vivo assay. Sagami Chemical Research Institute Report IV, 30-50, 1993.
7.Dafforn A, Chen P, Deng G, Herrler M, Iglehart DM, Koritala S, Lato SM, Pillarisetty S, Purohit R, Turner L, Wang M, Wang S, Kurn N.  Ribo-SPIA™, a rapid isothermal RNA amplification method for gene expression analysis.  In “Biochips as pathways to drug discovery”, Carmen A, Hardiman G, eds., CRC Press, 261-279, 2006.
Patent
Authorized patent:
1. Deng Yaguang, Zhang Jie, Tian Fang. A method and apparatus for cell enrichment, separation and extraction and single cell analysis method, invention patent number: ZL 2012 1 0181973.0, China.
2. Deng Yaguang, Deng Weiping. A single cell molecular biology identification method, invention patent number: ZL2011 1 0172843.6, China.
3. Deng Yaguang, Deng Weiping, Deng Jiangping. A magnetic head for separating magnetic beads and their combinations, utility model patent number: ZL 201420382458.3, China.
Application for patent in public:
1. Deng Yaguang, Deng Cunchang, Deng Weiping. A method for separating and enriching target cells from tissues, 201110005376.8, China.
2. Glenn Deng. Methods for single cell gene amplification and analysis. 20120315639, US. (Single Cell Gene Amplification and Analysis)
3、Glenn Y. Deng, Jie Zhang, Fang Tian. Methods and apparatus for single cells isolation and analyses. 20120315639, US. (Method and apparatus for single cell capture and analysis)
4, Jie Zhang, Glenn Y. Deng, Fang Tian. Floating magnet probe for cell isolation. 20120252088, US. (Design of floating magnet for cell capture)
5, Glenn Y. Deng, Jie Zhang, Fang Tian. Cancer cell detection and purification from body fluid using magnetic enrichment system. 61625121, US. (Magnetic enrichment system for detection and purification of body fluid cancer cells)
6. Glenn Y. Deng, Jing Zhang. Methods and apparatus for target cells enrichment, isolation and biological analysis. 61769195, US. (Methods and apparatus for enrichment, capture and biological analysis of target cells)
7. J. Zhang, Glenn Y. Deng.  Apparatus and method to enhance field gradient for magnetic rare cell separation.  61771802, US. (Instrument apparatus and method for enhancing magnetic field strength for capture of rare cells)
8. Deng Yaguang, Brian Deng, Deng Jiangping. A method for selectively amplifying RNA, invention patent number: 201510102011.5, China.
9. Deng Yaguang, Brian Deng, Deng Jiangping. A kit for detecting and identifying circulating tumor cells and its application, invention patent application number: 201510102012.X
10, Deng Yaguang,  a controllable nucleic acid extraction method. 201510153982.2, Chinese invention patent.
11. Deng Yaguang, a controllable nucleic acid extraction method. PCT/CN2015/075767, International Invention Patent (PCT).
Research project
1. Japanese Human Genome Project: Human new genes discovery and full cDNA library construction (PI: Kato, Deng), 1992-1993, Sagami Chemical Research Center.
2. Type II diabetes associated gene mutation analysis (PI: She, Deng), 1993-1995, University of Florida, Department of Pathology.
3. Candidate gene mutation analysis for PWS and AS (PI: Driscoll, Deng) , 1995-1997, University of Florida, Department of Pediatric Genetics.
4. LDH gene expression regulation factors (PI: Powers, Deng) , 1997-1998, Stanford University, Department of Biological Sciences.
5. IL-10 gene knock out b-cell gene expression profiling (PI. Deng), 1998-1999, Corporate research project, DNA Research Institute.
6. Cancer related gene expression GeneChip development(PI. Deng), 1999-2000, Corporate research project, Affymetrix.
7. DNA mismatch repair and SNP detection(PI. Deng), 2000-2001, Corporate research project, DNA Sciences Inc.
8. SPIA gene amplification for GeneChip analysis (PI. Deng), 2001-2004, Corporate research project, NuGEN Technologies Inc.
9. Circulation tumor cell enrichment and detection (PI. Deng, Burke), 2005-2009, Corporate research project , Applied Imaging/Genetix/Leika.
10. Cancer marker detection with biosensor technology(PI. Deng), 2009, Corporate research project,  Axela Biosensor.
11. Circulating tumor cell identification and mutation analysis in breast cancer patients (PI. Jeffrey, Deng), 2009-2012, Stanford University Breast cancer project, Stanford University, School of Medicine, Department of Surgical Oncology, Cancer Center.
12. Extraction and identification of blood circulating tumor cells, Wuhan 3551, 1 million, 2011-2014 (PI).
13. Single cell molecular analysis technology and products, Hubei Bairen Project, 2 million, 2013-2015 (PI).
14. Development of magnetic technology for blood circulation tumor cell detection. Hubei Provincial Science and Technology Department, 200,000, 2013-2015 (PI).
15. Blood circulation tumor cell molecular detection and identification. Guangdong Provincial Department of Science and Technology, 300,000, 2015-2016 (PI).