Xuan Huang, Ph.D.
Associate Researcher, The Institute of Translational Medicine
Nanchang University
Email: huangxuan@ncu.edu.cn
Education
2005.9- 2010.6 Ph.D. in Microbiology, College of Life Sciences, Wuhan University,
Wuhan, China
2000.9-2004.6 B.E.(Bachelor of Engineering) in Biological engineering, School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, China
Work Experience
7, 2010 - 6, 2012 Postdoctoral Fellow, Center for Experimental Medicine
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
6, 2012 - present Associate Researcher, The Institute of Translational Medicine Nanchang University, Nanchang, Jiangxi, China
9, 2016 - present Visiting Scholar, School of Medicine
University of Missouri Kansas City, Kansas City, Missouri, America
Research Interests
1). Screening of anti-tumor peptides and peptide drugs for cardiovascular and cerebrovascular diseases; 2). Molecular mechanisms of cardiac hypertrophy and myocardial infarction; 3). Screening of key proteins in tumor-related signaling pathways and related function studies; 4). New regulatory mechanisms of inflammatory response.
Grants
1.2017.1-2020.12: National Nature Science Foundation of China (81660390), Role of TRIM14 in the development of non-small lung cancer and its molecular mechanism
2.2014.1-2016.12: National Nature Science Foundation of China (81301964), Screening and application of anticancer peptide drugs based on S-phase kinase-associated protein 2
3.2014.1-2016.12: Postgraduate Student Foundation for New Teacher from the Ministry of Education of China (20133601120013), The regulation mechanism and function studies of hedgehog signaling pathway receptor smoothened in gastric cancer
4.2014.1-2016.12: Foundation from Department of Education of Jiangxi (GJJ14194), Screening of new Skp2 interacting proteins and the function studies
Publications
1.Xuan Huang, Mingjie Huang, Lingbao Kong, YongLi*. miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma. Cell Proliferation 2015; 48: 593-599.
2.Wei Wang#, Xuan Huang#, Hong-Bo Xin, Mingui Fu, AiminXue, Zhao-Hui Wu*. TRAF family member-associated NF-κBactivator(TANK) inhibits genotoxic nuclear factor κB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase. The Journal of Biological Chemistry 2015, 290(21): 13372-13385.(#Co-first authors)
3.Xuan Huang, Yong Li, Lingfang Wang, Jia Shao, Shiwen Luo*. POMP interacts with Suppressor of Fused in regulating Hedgehog signaling. Chinese Journal of Biochemistry and Molecular Biology 2012; 28(6): 522-530.
4.Xuan Huang, Weilong Zhang, Qintian Luo, Yong Li, Junyan Zhang, Libin Deng, NonghuaLv, Shiwen Luo*. Gene expression profiling of Hedgehog signaling pathway inhibition in human colon cancer cells. Chinese Journal of Cell Biology 2012; 34(9): 886-898.
5.Xuan Huang,Yong Li, Hui Fang, Congyi Zheng*. Establishment of persistent infection with foot-and-mouth disease virus in BHK-21 cells. Virology Journal 2011; 8: 169.
6.Xuan Huang, Yong Li, Cong-yi Zheng*. A novel single-cell quantitative real-time RT-PCR method for quantifying foot-and-mouth disease viral RNA. Journal of Virological Methods 2009; 155: 150-156.
7.Jia Shao, Linlin Xu, Limin Chen, Quqin Lu, Xinsheng Xie, Wei Shi, Huanting Xiong, Chao Shi, Xuan Huang, Jinhong Mei, Hai Rao, Hua Lu, Nonghua Lu, Shiwen Luo*. Arl13b promotes gastric tumorigenesis by regulating Smo trafficking and activation of the Hedgehog signaling pathway. Cancer Research 2017; 77(15): 4000-4013.
8.Yao Wang, Yong Li, Guanghui Hu, Xuan Huang, Hai Rao, XiangyangXiong, Zhijun Luo, Quqin Lu, Shiwen Luo*. Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory. Cellular Signalling 2016; 28: 1304-1313.
9.Chao Shi, Xuan Huang, Bin Zhang, Dan Zhu, Huqiao Luo, Quqin Lu, Wen-Cheng Xiong, Lin Mei*, Shiwen Luo*. The inhibition of heat shock protein 90 facilitates the degradation of poly-alanine expanded poly(A) binding protein nuclear 1 via the carboxyl terminus of heat shock protein 70-interacting protein. PLoS ONE 2015; 10(9): e0138936.
10.Xiaojian Han*, Zhangjian Yang, Liping Jiang, Yongfang Wei, Mingfang Liao, Yisong Qian, Yong Li, Xuan Huang, Jianbin Wang, Hongbo Xin, Yuying Wan*. Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. International Journal of Oncology 2015; 46: 691-700.
11.Hu Zhang, Yong Li, Xuan Huang, Congyi Zheng*. Global transcriptional analysis of model of persistent FMDV infection reveals critical role of host cells in persistence. Veterinary Microbiology 2013; 162: 321-329.
12.Yong Li, Xuan Huang, Jing Yang, Junyan Zhang, Lingfang Wang, Shiwen Luo*. Screening of interacting proteins of tumor suppressor SuFu by yeast two-hybrid. Journal of Wuhan University (Nature Science Edition) 2013; 59(4): 351-356.
13.Yong Li, Linlin Xu, Xuan Huang, Dengliang Huang, Wenjun Xu, NonghuaLv, Shiwen Luo*. Abnormal Activation of the Hedgehog Signaling Pathway in Esophageal Cancer. Chinese Journal of Clinical Oncology 2012; 39(22): 1761-1764.
14.Yong Li, Xuan Huang, Bo Xia, Congyi Zheng*. Development and validation of a duplex quantitative real-time RT-PCR assay for simultaneous detection and quantitation of foot-and-mouth disease viral positive-stranded RNAs and negative-stranded RNAs. Journal of Virological Methods 2009; 161: 161-167.
