Han Renwen, Associate Researcher, Master's Tutor
Institute of Translational Medicine, Nanchang University
Ganjiang Young Scholars in the First "215 Talents Project" of Nanchang University
Email: hrenwen@126.com
Education experience:
2004/09-2009/06, Ph.D., Biochemistry and Molecular Biology, Lanzhou University
2000/09-2004/06, Bachelor of Biology, Lanzhou University
Work experience:
2013/09 - Associate Researcher, Institute of Translational Medicine, Nanchang University
2011/07-2013/04, Associate Fellow, Shenzhen Research Institute, Hong Kong Polytechnic University
2009/07-2011/06, Shenzhen Research Institute, Hong Kong Polytechnic University, postdoctoral
At present, the main research directions are as follows:
Study on the Regulation and Mechanisms of Neuropeptides on Learning and Memory
Molecular Mechanisms of Learning and Memory Regulation
Scientific research topics and funding:
1. National Natural Science Foundation of China, the role and mechanism of endoplasmic reticulum Ca2+ channel regulatory protein FKBP12.6 in conditional fear memory, 2018/1-2020/12, 201,000, hosted
2. National Natural Science Foundation of China, the regulation of orphanin in the olfactory cortex on object recognition and memory, and its mechanism, 2015/1-2018/12, 470,000, hosted
3. Jiangxi Provincial Science and Technology Department Youth Fund, the role and mechanism of orphanin in the recognition and memory of new objects, 2014/1-2016/12, 50,000, hosted
4. Jiangxi Provincial Department of Education Youth Fund, neuropeptide apelin regulation and mechanism in the recognition of new objects, 2014/1-2016/12, 10,000, hosted
Mainly published articles (*Corresponding author):
1.Han Ren-wen, Xu Hong-jiao, Zhang Rui-san, Wang Pei, Chang Min, Peng Ya-li, Deng Ke-yu, Wang Rui*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiology of Learning and Memory 107, 32–6, 2014 (IF=3.543)
2.Han Ren-wen, Xu Hong-jiao, Zhang Rui-san, Wang Rui*. The role of apelin-13 in novel object recognition memory. Peptides 62, 155–8, 2014 (IF=2.778)
3.Han Ren-wen, Zhang Rui-san#, Xu Hong-jiao, Chang Min, Peng Ya-li, Wang Rui*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Aβ1-42 in mice novel object recognition task. Neuropharmacology, 70C, 261-7, 2013 (IF=5.012)
4.Han Ren-wen; Zhang Rui-san, Chang Min, Peng Ya-li, Wang Pei, Hu Sheng-quan, Choi Chung-lit, Yin Ming, Wang Rui*, Han Yi-fan*. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Research, 1470:59-68, 2012 (IF=2.746)
5.Han Ren-wen, Yin Xin-qiang, Chang Min, Peng Ya-li, Li Wei, Wang Rui*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-D-aspartate receptor antagonist in mice. Neuroscience Letters, 455(1), 74-7, 2009. (IF=2.180)
6.Han Ren-wen, Chang Min#, Peng Ya-li, Qiao Lian-yong, Yin Xin-qiang, Li Wei, Wang Rui*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides, 30(7), 1313-7, 2009 (IF=2.778)
7.Peng Ya-li, Han Ren-wen#, Chang Min, Zhang Lei, Zhang Rui-san, Li Wei, Han Yi-fan*, Wang Rui*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides, 31(12), 2259-63, 2010 (IF=2.778)
8.Liu Zhi-Peng, He Qing-Hai, Pan Han-Qing, Xu Xiao-Bin, Chen Wen-Bing, He Ye, Zhou Jin, Zhang Wen-Hua, Zhang Jun-Yu, Ying Xiao-Ping, Han Ren-Wen, Li Bao-Ming, Gao Tian-Ming, Bing-Xing Pan*. Delta Subunit-Containing Gamma-Aminobutyric Acid A Receptor Disinhibits Lateral Amygdala and Facilitates Fear Expression in Mice. Biological Psychiatry, 81(12):990-1002, 2017(IF=11.412).
9.Zhang Rui-san, Xu Hong-jiao, Jiang Jing-hong, Han Ren-wen, Chang Min, Peng Ya-li, Wang yuan, Wang Rui*. Endomorphin-1 attenuates Aβ42 induced impairment of novel object and object location recognition tasks in mice. Brain Research 1629: 210-20, 2015 (IF=2.746)
10.Li Ming-sheng, Peng Ya-li, Jiang Jing-hong, Xue Hong-xiang, Wang Pei, Zhang Pei-jiang, Han Ren-wen, Chang Min*, Wang Rui*. Neuropeptide S Increases locomotion activity through corticotropin-releasing factor receptor 1 in substantia nigra of mice. Peptides 71, 196-201, 2015 (IF=2.778)
11.Jiang Jing-hong, He Zhen, Peng Ya-li, Jin Wei-dong, Wang Zhe, Han Ren-wen, Chang Mi*, Wang Rui*. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Abeta1-42 in mice novel object and object location recognition tasks. Neurobiology of learning and memory 123, 187-195, 2015 (IF=3.543)
12.Cui Wei, Zhang Zai-jun, Li Wen-ming, Hu Sheng-quan, Mak Shing-hung, Zhang Huan, Han Ren-wen, Yuan Shuai, Li Sai, Sa Fei, Xu Da-ping, Lin Zhi-xiu, Zuo Zhong, Rong Jian-hui, Ma Edmond Dik-Lung, Choi Tony Chunglit, Lee Simon M.Y., Han Yi-fan*. Unexpected protection against MPP(+) -induced neurotoxicity via selectively and directly inhibiting neuronal NOS by anti-cancer agent SU4312. British Journal of Pharmacology, 168(5), 1201-14, 2013 (IF=5.491)
13.Hu Sheng-quan, Han Ren-wen, Mak Shing-hung, Han Yi-fan*. Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. Journal of Ethnopharmacology, 135(1), 34-42, 2011 (IF=2.981)
14.Cui Wei, Li Wen-ming, Han Ren-wen, Mak Shing-hung, Zhang Huan, Hu Sheng-quan, Rong Jian-hui, Han Yi-fan*. PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochemistry International, 59(6), 945-53, 2011 (IF=3.262)
15.Zhang Huan, Mak Shing-hung, Cui Wei, Li Wen-ming, Han Ren-wen, Hu Sheng-quan, Ye Min-zhong, Pi Rong-biao, Han Yi-fan*. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry International, 59(7), 981-8, 2011 (IF=3.262)
16.Zhao Yu-ming, Dou Juan, Luo Jia-lie, Li Wen-ming, Chan Hugh H. N., Cui Wei, Zhang Huan, Han Ren-wen, Carlier Paul R., Zhang Xue-jun, Han Yi-fan*. Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets. Brain Research, 1421, 100-9, 2011 (IF=2.746)
17.Peng Ya-li, Zhang Jian-nan, Chang Min, Li Wei, Han Ren-wen, Wang Rui*. Effects of central neuropeptide S in the mouse formalin test. Peptides, 31(10), 1878-83, 2010 (IF=2.778)
18.Li Wei, Chang Min, Peng Ya-li, Gao Ya-hu, Zhang Jian-nan, Han Ren-wen, Wang Rui*. Neuropeptide S produces antinociceptive effects at the supraspinal level in mice. Regulatory Peptides, 156(1-3), 90-5, 2009 (IF=2.014)
19.Chang Min, Li Wei, Peng Ya-li, Gao Ya-hu, Yao Jia, Han Ren-wen, Wang Rui*. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] gamma2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Research, 1271, 36-48, 2009 (IF=2.746)
20.Li Wei, Gao Ya-hu, Chang Min, Peng Ya-li, Yao Jia, Han Ren-wen, Wang Rui*. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides, 30(2), 234-40, 2009 (IF=2.778)
21.Peng Ya-li, Chang Min, Dong Shou-liang, Li Wei, Han Ren-wen, Fu Guo-xin, Chen Qiang, Wang Rui*. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regulatory Peptides, 134(2-3), 75-81, 2006 (IF=2.014)
22.Chang Min, Peng Ya-li, Dong Shou-liang, Han Ren-wen, Li Wei, Yang Ding-jian, Chen Qiang, Wang Rui*. Structure-activity studies on different modifications of nociceptin/orphanin FQ: identification of highly potent agonists and antagonists of its receptor. Regulatory Peptides, 130(3), 116-22, 2005 (IF=2.014)
